Patient Resources
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Patient Resources

Patient Resources

Patient Resources

Particularly when SYNTHROID is written in a non-protective manner for the state language. Most, but not all, levothyroxine products have been determined to be therapeutically equivalent by the FDA. It may take several weeks before your body starts to respond to Synthroid.

  • The second is that Synthroid has a history, as physicians have been treating patients with hypothyroidism with Synthroid for over 65 years.
  • Certain other medicines may also increase or decrease the effects of Synthroid.
  • SYNTHROID is contraindicated in patients with uncorrected adrenal insufficiency see Warnings and Precautions (5.4).
  • Additional laboratory testing and clinical findings may be necessary.
  • Circulating thyroid hormones are greater than 99% bound to plasma proteins, including thyroxine-binding globulin (TBG), thyroxine-binding prealbumin (TBPA), and albumin (TBA), whose capacities and affinities vary for each hormone.

PRIMARY HYPOTHYROIDISM DOSING GUIDELINES

Published studies report that levothyroxine is present in human milk following the administration of oral levothyroxine. No adverse effects on the breastfed infant have been reported and there is no information on the effects of levothyroxine on milk production. Adequate levothyroxine treatment during lactation may normalize milk production in hypothyroid lactating mothers with low milk supply. Patients need to feel comfortable to alert me of any changes in their status in terms of their symptoms. But also specific medical changes that may indicate there may be a need for a dose change or something that could have affected their thyroid hormone levels.

Because the long-acting nature of the medication, I do indicate that it may take several months to see an improvement in both of these levels. Levothyroxine is one of the ten NTI drug classes most commonly prescribed. These medications are those where small changes in the dose or blood concentration may lead to serious synthroid overdose therapeutic failures and/or adverse drug reactions. The estimated background risk of major birth defects and miscarriage for the indicated population is unknown. All pregnancies have a background risk of birth defect, loss, or other adverse outcomes.

9 Drug-Food Interactions

  • DAW-1 indicates that substitution is not allowed, based on the prescriber’s preference, and ensures your patient will receive the treatment you prescribe.
  • Carefully monitor glycemic control, especially when thyroid therapy is started, changed, or discontinued see Warnings and Precautions (5.5).
  • Administer SYNTHROID at least 4 hours before or after drugs known to interfere with SYNTHROID absorption see Drug Interactions (7.1).
  • Seizures occurred in a 3-year-old child ingesting 3.6 mg of levothyroxine.
  • The goal is to achieve steady TSH levels within the appropriate therapeutic range.

Addition of SYNTHROID therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Carefully monitor glycemic control, especially when thyroid therapy is started, changed, or discontinued see Warnings and Precautions (5.5). Thyroid hormone increases metabolic clearance of glucocorticoids. Initiation of thyroid hormone therapy prior to initiating glucocorticoid therapy may precipitate an acute adrenal crisis in patients with adrenal insufficiency. Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID see Contraindications (4). Treat patients with adrenal insufficiency with replacement glucocorticoids prior to initiating treatment with SYNTHROID see CONTRAINDICATIONS.

Depending on patient circumstances, cost can sometimes be a concern. There are options available to assist the patient with cost concerns. Careful titration of medication and monitoring is required in that setting.

Absorption of orally administered T4 from the gastrointestinal tract ranges from 40% to 80%. The majority of the SYNTHROID dose is absorbed from the jejunum and upper ileum. The relative bioavailability of SYNTHROID tablets, compared to an equal nominal dose of oral levothyroxine sodium solution, is approximately 93%.

In patients on a stable and appropriate replacement dosage, evaluate clinical and biochemical response every 6 to 12 months and whenever there is a change in the patient’s clinical status. SYNTHROID is indicated in adult and pediatric patients, including neonates, as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. HypothyroidismSYNTHROID® (levothyroxine sodium) tablets, for oral use is indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism. For secondary or tertiary hypothyroidism, serum TSH is not a reliable measure of SYNTHROID dosage adequacy and should not be used to monitor therapy.

Side Effects for Synthroid

When prescribing SYNTHROID, protecting your script can ensure your patients receive SYNTHROID every time they refill their prescription. SYNTHROID is not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis. The FDA has determined that certain levothyroxine products are interchangeable. So, it’s not just treating a number and following the TSH, it’s also making sure that the patient’s symptoms have improved.

Our Synthroid Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Long-term carcinogenicity studies in animals to evaluate the carcinogenic potential of levothyroxine have not been performed. Studies to evaluate mutagenic potential and animal fertility have not been performed. A portion of the conjugated hormone reaches the colon unchanged and is eliminated in the feces.

  • Euthyrox (levothyroxine) is used to treat hypothyroidism and to treat or prevent goiter.
  • Closely monitor infants during the first 2 weeks of SYNTHROID therapy for cardiac overload and arrhythmias.
  • When prescribing SYNTHROID, protecting your script can ensure your patients receive SYNTHROID every time they refill their prescription.
  • You should refer to the prescribing information for Synthroid for a complete list of interactions.
  • There are safety considerations as SYNTHROID should not be used for treatment of obesity or for weight loss.

DRUG INTERACTIONS

Stop biotin and biotin-containing supplements for at least 2 days prior to thyroid testing. If so, advise them to stop biotin supplementation at least 2 days before assessing TSH and/or T4 levels see DOSAGE AND ADMINISTRATION and DRUG INTERACTIONS. By visiting Synthroid.com, patients can access additional support and resources to understand and manage their hypothyroidism. The Before Breakfast Club is a program designed to help support your patients on SYNTHROID therapy. After joining, patients will receive exclusive benefits including savings, tips, and tools to help your patients make the most of their SYNTHROID treatment.

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